The outbreak killed 17 pigs and infected 44 in total among 546 farm workers in Yiyang City, according to the ministry's statement, quoted by the official Xinhua news agency.
The same note reveals that in the town of Changde, also in Hunan, the outbreak infected almost all the 268 pigs raised on a local farm and killed 31.
Local authorities have initiated an emergency mechanism to isolate, slaughter or disinfect pigs.
Thousands of pigs slaughtered
Tens of thousands of pigs have already been slaughtered in several provinces in an effort to halt the disease since the first outbreak was detected in early August in northeastern China.
The disease affects pigs and boars, but it is not transmissible to humans. However, it puts at risk the Chinese market, which annually produces 600 million pigs.
The meat of that animal is an essential part of Chinese cooking, making up 60% of the total consumption of animal protein in the country.
The price fluctuation of this type of meat is sensitive in China and the Government saves a large quantity frozen to put on the market when prices rise.